Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | CFTR | P13569 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11153695 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EGAAMAPTHSD17B10 | |
| SCHEMBL4251894 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EGAAMAPTHSD17B10 | |
| SCHEMBL13740239 | 0.87 | ALDH1A1 (0.59) | ALDH1A1KDM4EGAAMAPTHSD17B10 | |
| SCHEMBL22749335 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAMAPTHSD17B10 | |
| SCHEMBL21543853 | 0.85 | TDP1 (0.55) | ALDH1A1KDM4EMAPTTDP1LMNA | |
| SCHEMBL27122631 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4EGAAMAPTHSD17B10 | |
| SCHEMBL11833005 | 0.83 | KDM4E (0.53) | ALDH1A1KDM4EMAPTHSD17B10HPGD | |
| SCHEMBL18823988 | 0.83 | KDM4E (0.57) | ALDH1A1KDM4EMAPTTDP1LMNA | |
| SCHEMBL5952448 | 0.83 | PARP10 (0.56) | ALDH1A1KDM4EMAPTTDP1LMNA | |
| SCHEMBL858839 | 0.83 | ALDH1A1 (0.66) | ALDH1A1KDM4EGAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323819-B1 | COMBINATIONS OF RIP2 KINASE INHIBITOR PRODRUG 2-((4-(BENZO[D]THIAZOL-5-YLAMINO)-6-(TERT. -BUTYLSULFONYL)QUINAZOLIN-7-YL)OXY)ETHYL DIHYDROGEN PHOSPHATE WITH OTHER THERAPEUTIC AGENTS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-02-26 | — | — | EP | disclosed |
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4377581-A | ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4351940-A | Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4287341-A | USEFUL AS ANTIHYPERTENSIVE AGENTS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| EP-0028473-A1 | Chloro- and alkoxy-substituted-2,4-diaminoquinazolines and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | disclosed |