SCHEMBL858839

SCHEMBL858839

COC(=O)c1ccc(OC)cc1N

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.66
KDM4E B2RXH2 8/20 0.66
GAA P10253 7/20 0.66
HSD17B10 Q99714 5/20 0.66
MAPT P10636 5/20 0.66
HPGD P15428 5/20 0.66
GLA P06280 2/20 0.66
CASP1 P29466 1/20 0.66
CASP7 P55210 1/20 0.66
ATM Q13315 1/20 0.66
ABL1 P00519 1/20 0.64
CFTR P13569 2/20 0.58
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.52
MEN1 O00255 2/20 0.52
THRB P10828 2/20 0.52
KMT2A Q03164 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL267307 0.85 KDM4E (0.62) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL9929149 0.85 NPC1 (0.63) ALDH1A1KDM4EGAAHSD17B10MAPT
Hydrochloric Acid SCHEMBL5100210 0.84 ALDH1A1 (0.60) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL312677 0.83 ALDH1A1 (0.65) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL148855 0.83 ALDH1A1 (0.53) ALDH1A1KDM4EGAAMAPTHPGD
SCHEMBL29976235 0.83 ALDH1A1 (0.65) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL147211 0.83 SMN1; SMN2 (0.54) ALDH1A1KDM4EGAAMAPTHPGD
SCHEMBL22749333 0.83 ALDH1A1 (0.58) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL7685381 0.83 CFTR (0.65) ALDH1A1KDM4EGAAHSD17B10MAPT
SCHEMBL10362606 0.83 ALDH1A1 (0.58) ALDH1A1KDM4EGAAHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 283 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
EP-4733299-A1 SULFUR-CONTAINING FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shenzhen Braegen Pharmaceutical Co., Ltd. (CN) 2026-04-29 EP disclosed
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 US disclosed
US-20260085058-A1 DEGRADERS OF SON OF SEVENLESS HOMOLOG 1 YUAN YU (US) 2026-03-26 US disclosed
US-12565511-B2 SOS1 inhibitor containing phosphorus CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2026-03-03 US disclosed
US-20260022135-A1 ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF 1CBIO INC (US) 2026-01-22 US disclosed
US-12485169-B2 Compounds Grey Wolf Therapeutics Limited (GB) 2025-12-02 US disclosed
US-20250243171-A1 QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE ARTHROSI THERAPEUTICS, INC. 2025-07-31 US disclosed
US-12325720-B2 Ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP1) inhibitors and uses thereof 1CBIO, INC. (US) 2025-06-10 US disclosed
CN-115677601-B Compound with anti-tumor activity and application thereof 石药集团中奇制药技术(石家庄)有限公司 2025-06-03 CN disclosed
EP-0093922-A2 Benzoxazin-2-ones, their preparation and therapeutic agents containing these compounds Dr. Karl Thomae GmbH (DE) 1983-11-16 EP disclosed
US-4377581-A ANTIHYPERTENSIVE AGENTS PFIZER INC. (US) 1983-03-22 US disclosed
US-4351940-A Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines PFIZER INC. (US) 1982-09-28 US disclosed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US disclosed
US-4287341-A USEFUL AS ANTIHYPERTENSIVE AGENTS PFIZER INC. (US) 1981-09-01 US disclosed
EP-0028473-A1 Chloro- and alkoxy-substituted-2,4-diaminoquinazolines and pharmaceutical compositions containing them PFIZER INC. (US) 1981-05-13 EP disclosed
US-4260540-A SPIN DYEING POLYACRYLONITRILE BAYER AKTIENGESELLSCHAFT (DE) 1981-04-07 US disclosed
US-4246401-A Axomethine pigments BAYER AKTIENGESELLSCHAFT (DE) 1981-01-20 US disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4014863-A LACQUERS, PRINTING INKS, PAINTS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022135-A1 ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF ENPP1, ENPP3, NCEH1 ALDH1A1 2453/4885KDM4E 4523/4885GAA 1454/4885
US-20250243171-A1 QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE EGFR, ABL1, ERBB2 ALDH1A1 2795/4885KDM4E 3572/4885GAA 1111/4885
US-12565511-B2 SOS1 inhibitor containing phosphorus SOST, SOS1, SOS2 ALDH1A1 4510/4885KDM4E 4495/4885GAA 3203/4885
US-12325720-B2 Ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP1) inhibitors and uses thereof ENPP1, ENPP3, ENPP2 ALDH1A1 754/4885KDM4E 3129/4885GAA 189/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 ALDH1A1 1507/4885KDM4E 3921/4885GAA 2559/4885
US-12485169-B2 Compounds SLC10A1, VHL, CFTR ALDH1A1 276/4885KDM4E 4372/4885GAA 96/4885
US-20260085058-A1 DEGRADERS OF SON OF SEVENLESS HOMOLOG 1 SOS1, KRAS, SOS2 ALDH1A1 1136/4885KDM4E 924/4885GAA 4426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.