Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Phthalate SCHEMBL28111561 | 0.82 | GRM8 (0.55) | TSHRALDH1A1LTA4HHSD17B10CYP1A2 | |
| SCHEMBL176835 | 0.79 | NPC1 (0.51) | KDM4EALDH1A1LTA4HHSD17B10HPGD | |
| SCHEMBL176836 | 0.79 | NPC1 (0.51) | KDM4EALDH1A1LTA4HHSD17B10HPGD | |
| SCHEMBL25904137 | 0.79 | TSHR (0.65) | TSHRTDP1KMT2AGAAKDM4E | |
| SCHEMBL28447277 | 0.78 | LTA4H (0.49) | LTA4HCYP1A2LNPEPERAP2L3MBTL1 | |
| SCHEMBL6715728 | 0.78 | TSHR (0.60) | TSHRTDP1KMT2AGAAKDM4E | |
| SCHEMBL28304178 | 0.78 | TSHR (0.60) | TSHRTDP1KMT2AGAAKDM4E | |
| SCHEMBL14426829 | 0.77 | KDM4E (0.74) | TSHRTDP1KMT2AGAAKDM4E | |
| SCHEMBL10362634 | 0.77 | TSHR (0.56) | TSHRTDP1KMT2AGAAKDM4E | |
| SCHEMBL10364418 | 0.77 | GAA (0.69) | TSHRKMT2AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |