Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364533 | 0.86 | ITGB3 (0.58) | ALDH1A1ALOX12SMN1; SMN2ITGB3ITGB1 | |
| SCHEMBL5763695 | 0.83 | ITGB1 (0.79) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL10362638 | 0.81 | TACR1 (0.57) | KDM4EALDH1A1HSD17B10HPGDALOX12 | |
| SCHEMBL10362594 | 0.80 | TACR1 (0.67) | TACR1ATM | |
| SCHEMBL5736480 | 0.77 | ITGB3 (0.53) | KDM4EALDH1A1ITGB3ITGB1ITGAV | |
| SCHEMBL10362476 | 0.77 | TACR1 (0.53) | KDM4EALDH1A1HSD17B10HPGDALOX12 | |
| SCHEMBL5734401 | 0.77 | NPC1 (0.63) | KDM4EALDH1A1ALOX12SMN1; SMN2ITGB3 | |
| Iodide SCHEMBL10827466 | 0.76 | NPC1 (0.62) | KDM4EALDH1A1ALOX12SMN1; SMN2ITGB3 | |
| SCHEMBL4385648 | 0.73 | TSHR (0.72) | KDM4EALDH1A1HSD17B10NPSR1TSHR | |
| SCHEMBL10524606 | 0.73 | TSHR (0.72) | KDM4EALDH1A1HSD17B10NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |