Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPID | Q08752 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364557 | 0.86 | ALDH1A1 (0.67) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10363344 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10362913 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10364427 | 0.80 | KDM4E (0.62) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10362622 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4EGAAMAPTTSHR | |
| SCHEMBL10363510 | 0.78 | KDM4E (0.71) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10364261 | 0.77 | KDM4E (0.74) | ALDH1A1KDM4EGAAKMT2AHPGD | |
| SCHEMBL7746192 | 0.77 | KDM4E (1.00) | ALDH1A1KDM4EGAAKMT2AHPGD | |
| SCHEMBL10364357 | 0.75 | ALDH1A1 (0.60) | ALDH1A1KDM4EGAAMAPTNAMPT | |
| SCHEMBL10362885 | 0.74 | KDM4E (0.74) | ALDH1A1KDM4EGAAMAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |