Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CFD | P00746 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746192 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL10364427 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL10362978 | 0.79 | POLB (0.60) | ALDH1A1GAAPOLBKMT2AHSD17B10 | |
| SCHEMBL10364349 | 0.78 | ALDH1A1 (0.69) | KDM4EALDH1A1GAAPOLBCFD | |
| SCHEMBL12888221 | 0.77 | TSHR (0.46) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10364422 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL1514314 | 0.77 | KDM4E (0.84) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL5604458 | 0.76 | HDAC1 (0.76) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL20236378 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1GAAGSK3BPOLB | |
| SCHEMBL4081297 | 0.76 | ALDH1A1 (0.60) | KDM4EALDH1A1GAAGSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |