Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | AHCY | P23526 | 4/20 | 0.53 |
| ▸ | PNP | P00491 | 3/20 | 0.51 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | TK1 | P04183 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364294 | 1.00 | ADORA3 (0.54) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL10364278 | 1.00 | ADORA3 (0.54) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL10364276 | 1.00 | ADORA3 (0.54) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL10171928 | 0.92 | ADORA3 (0.52) | ADORA3AHCYPNPHPRT1STING1 | |
| SCHEMBL600702 | 0.92 | ADORA3 (0.52) | ADORA3AHCYPNPHPRT1STING1 | |
| SCHEMBL600701 | 0.92 | ADORA3 (0.52) | ADORA3AHCYPNPHPRT1STING1 | |
| SCHEMBL10647267 | 0.92 | ADORA3 (0.54) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL9367067 | 0.91 | AHCY (0.60) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL10516308 | 0.91 | AHCY (0.60) | ADORA3AHCYPNPHPRT1ADORA2B | |
| SCHEMBL10516867 | 0.91 | AHCY (0.60) | ADORA3AHCYPNPHPRT1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212956-B1 | GUANINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4857531-A | Guanine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-15 | — | — | US | disclosed |
| EP-0212956-A1 | Guanine derivatives | GLAXO GROUP LIMITED (GB) | 1987-03-04 | — | — | EP | disclosed |