Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227218 | 0.85 | ALDH1A1 (0.71) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10363345 | 0.84 | KDM4E (0.54) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL27203069 | 0.84 | KDM4E (0.74) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10364417 | 0.84 | KDM4E (0.54) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL9510448 | 0.83 | GAA (0.53) | MAPTKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL10363762 | 0.82 | KDM4E (0.53) | MAPTKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL10362862 | 0.81 | SMN1; SMN2 (0.57) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL5928755 | 0.80 | ABL1 (0.58) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL7256022 | 0.79 | KCNMA1 (0.55) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL10362881 | 0.79 | KDM4E (0.76) | MAPTKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |