Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364657 | 1.00 | CYP3A4 (0.40) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL7409783 | 0.77 | MAPT (0.53) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL7409786 | 0.77 | MAPT (0.53) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL10364607 | 0.77 | MAPT (0.38) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL10364609 | 0.77 | MAPT (0.38) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL8629745 | 0.76 | IDO1 (0.49) | CYP3A4BAZ2BMAPTIDO1KDM4E | |
| SCHEMBL8629749 | 0.76 | IDO1 (0.49) | CYP3A4BAZ2BMAPTIDO1KDM4E | |
| SCHEMBL10363574 | 0.75 | FBP1 (0.38) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL10363576 | 0.75 | FBP1 (0.38) | CYP3A4BAZ2BMAPTENPP2MKNK1 | |
| SCHEMBL10365507 | 0.74 | IDO1 (0.44) | CYP3A4BAZ2BMAPTENPP2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175187-B1 | 3,4-DIHYDRO-2(1H)-PYRIDONES AND 2(1H)-PYRIDONES CONTAINING IMIDAZOLE GROUPS, METHOD FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1990-01-10 | — | — | EP | disclosed |
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |