Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MITF | O75030 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409783 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL8629749 | 0.84 | IDO1 (0.49) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL8629745 | 0.84 | IDO1 (0.49) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL11204355 | 0.81 | FBP1 (0.62) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL10364657 | 0.77 | CYP3A4 (0.40) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL10364656 | 0.77 | CYP3A4 (0.40) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL10363574 | 0.76 | FBP1 (0.38) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL10363576 | 0.76 | FBP1 (0.38) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL12050306 | 0.75 | FBP1 (0.67) | MAPTMEN1KMT2AMITFALDH1A1 | |
| SCHEMBL4700604 | 0.75 | FBP1 (0.67) | MAPTMEN1KMT2AMITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |