Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.46 |
| ▸ | PPARA | Q07869 | 14/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366899 | 0.86 | PPARG (0.44) | PPARGPPARAFFAR1PPARDKDM4E | |
| SCHEMBL10365636 | 0.82 | KDM4E (0.56) | PPARGPPARAKDM4E | |
| SCHEMBL10367498 | 0.82 | TDP1 (0.38) | KDM4E | |
| SCHEMBL10366768 | 0.78 | PPARG (0.50) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL10365461 | 0.77 | HPGD (0.51) | — | |
| SCHEMBL10365459 | 0.77 | HPGD (0.51) | — | |
| SCHEMBL7736876 | 0.77 | PPARG (0.74) | PPARGPPARAPPARD | |
| SCHEMBL8458685 | 0.76 | PPARG (0.43) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL131888 | 0.76 | PPARG (0.55) | PPARGPPARAFFAR1 | |
| SCHEMBL10365639 | 0.76 | PPARG (0.43) | PPARGPPARAFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |