Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.74 |
| ▸ | PPARA | Q07869 | 17/20 | 0.74 |
| ▸ | PPARD | Q03181 | 9/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389208 | 0.91 | PPARG (0.79) | PPARGPPARAPPARD | |
| SCHEMBL3283978 | 0.90 | PPARG (0.77) | PPARGPPARAPPARD | |
| SCHEMBL10366261 | 0.89 | PPARG (0.59) | PPARGPPARAPPARD | |
| SCHEMBL7730857 | 0.89 | PPARA (0.60) | PPARGPPARAPPARD | |
| SCHEMBL5098728 | 0.88 | PPARG (0.76) | PPARGPPARAPPARD | |
| SCHEMBL24443095 | 0.88 | PPARG (0.72) | PPARGPPARAPPARD | |
| SCHEMBL7736913 | 0.88 | PPARG (0.58) | PPARGPPARAPPARD | |
| SCHEMBL9537307 | 0.88 | PPARG (0.71) | PPARGPPARAPPARD | |
| SCHEMBL12617119 | 0.87 | PPARG (0.74) | PPARGPPARAPPARD | |
| SCHEMBL10372016 | 0.87 | FFAR1 (0.65) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414001-B2 | Ether and amide compounds preparation thereof composition containing same and use thereof as antidiadetics | KOTOBUKI PHARMACEUTICAL CO. LTD. (JP) | 2002-07-02 | — | — | US | disclosed |
| US-20010008898-A1 | Ether and amide compounds and preparation of thereof as antidiadetics. | KOTOBUKI PHARMACEUTICAL CO., LTD. (JP) | 2001-07-19 | — | — | US | disclosed |
| US-6214842-B1 | TREATING METABOLIC DISORDERS RELATED TO INSULIN RESISTANCE OR HYPERGLYCEMIA TYPICALLY ASSOCIATED WITH OBESITY OR GLUCOSE INTOLERANCE; TREATING DIABETES TYPES I AND II | WYETH | 2001-04-10 | — | — | US | disclosed |
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5089514-A | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010008898-A1 | Ether and amide compounds and preparation of thereof as antidiadetics. | SLC5A2, GCG, NCEH1 | PPARG 428/4885PPARA 404/4885PPARD 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.