Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10365633 | 0.99 | DRD2 (0.56) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL10985997 | 0.81 | DRD2 (0.55) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL10373053 | 0.81 | DRD2 (0.55) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL10366616 | 0.80 | DRD2 (0.56) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL10991961 | 0.80 | DRD2 (0.52) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL1840347 | 0.80 | DRD2 (0.58) | DRD2DRD3DRD4GRM2HTR1A | |
| SCHEMBL9377459 | 0.79 | DRD2 (0.55) | DRD2DRD3DRD4GRM2HTR1A | |
| Bromide SCHEMBL10991850 | 0.79 | DRD2 (0.55) | DRD2DRD3DRD4GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL1836699 | 0.78 | DRD2 (0.57) | DRD2DRD3DRD4GRM2HTR1A | |
| Bromide SCHEMBL10365464 | 0.78 | DRD2 (0.57) | DRD2DRD3DRD4GRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127167-B1 | 3-(4-PIPERIDINYL)-1,2-BENZISOTHIAZOLES AND DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-04-04 | — | — | EP | claimed |
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | claimed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | claimed |