SCHEMBL10985997

SCHEMBL10985997

N#CCN1CCC(c2nsc3ccccc23)CC1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.55
DRD3 P35462 2/20 0.55
DRD4 P21917 1/20 0.55
GRM2 Q14416 1/20 0.55
HTR1A P08908 2/20 0.52
HTR2A P28223 2/20 0.52
JAK2 O60674 1/20 0.42
JAK1 P23458 1/20 0.42
TYK2 P29597 1/20 0.42
JAK3 P52333 1/20 0.42
ACHE P22303 2/20 0.41
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
SLC6A4 P31645 1/20 0.37
TLR9 Q9NR96 1/20 0.36
TLR8 Q9NR97 1/20 0.36
TLR7 Q9NYK1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10364685 0.82 DRD2 (0.49) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL10364952 0.81 DRD2 (0.57) DRD2DRD3DRD4GRM2HTR1A
Bromide SCHEMBL10365633 0.80 DRD2 (0.56) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL10988648 0.80 KDM2B (0.40) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL10373053 0.79 DRD2 (0.55) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL10366616 0.78 DRD2 (0.56) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL10991961 0.77 DRD2 (0.52) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL1840347 0.77 DRD2 (0.58) DRD2DRD3DRD4GRM2HTR1A
SCHEMBL9377459 0.77 DRD2 (0.55) DRD2DRD3DRD4GRM2HTR1A
Bromide SCHEMBL10991850 0.77 DRD2 (0.55) DRD2DRD3DRD4GRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4558056-A PSYCHOLOGICAL DISORDERS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1985-12-10 US disclosed
US-4524074-A TREATMENT OF PSYCHOSES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1985-06-18 US disclosed
EP-0127167-A2 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1984-12-05 EP disclosed
US-4458076-A ANALGESICS, ANTIPSYCHOTICS HOECHST-ROUSSEL PHARMACEUTICALS (US) 1984-07-03 US disclosed