Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2059447 | 0.84 | TSHR (0.55) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL22512408 | 0.79 | CYP3A4 (0.60) | MEN1KMT2ALMNAMAPTTDP1 | |
| SCHEMBL17289296 | 0.77 | CYP3A4 (0.60) | KMT2ALMNAMAPTTDP1ACHE | |
| SCHEMBL15820153 | 0.77 | CYP3A4 (0.60) | KMT2ALMNAMAPTTDP1ACHE | |
| SCHEMBL15825618 | 0.77 | CYP3A4 (0.57) | MEN1KMT2ALMNAMAPTTDP1 | |
| SCHEMBL17289288 | 0.77 | CYP3A4 (0.60) | KMT2ALMNAMAPTTDP1ACHE | |
| SCHEMBL2059305 | 0.75 | PTGS1 (0.64) | MEN1KMT2ALMNAMAPTACHE | |
| SCHEMBL17289308 | 0.75 | CYP3A4 (0.55) | MEN1KMT2ALMNAMAPTACHE | |
| SCHEMBL9690459 | 0.75 | ACHE (0.51) | MEN1KMT2AACHEMAOBRAB9A | |
| SCHEMBL10367354 | 0.75 | CYP3A4 (0.67) | KMT2ALMNAMAPTTDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |