Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MC3R | P41968 | 2/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | MC5R | P33032 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366130 | 1.00 | OPRM1 (0.62) | OPRM1OPRK1SIGMAR1ALDH1A1SMN1; SMN2 | |
| Sulfuric Acid SCHEMBL10372591 | 0.96 | OPRM1 (0.58) | OPRM1OPRK1SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10366724 | 0.94 | SIGMAR1 (0.65) | OPRM1OPRK1SIGMAR1KMT2A | |
| SCHEMBL10366726 | 0.94 | SIGMAR1 (0.65) | OPRM1OPRK1SIGMAR1KMT2A | |
| Hydrochloric Acid SCHEMBL10367914 | 0.93 | SIGMAR1 (0.64) | OPRM1OPRK1SIGMAR1KMT2A | |
| Hydrochloric Acid SCHEMBL10367913 | 0.93 | SIGMAR1 (0.64) | OPRM1OPRK1SIGMAR1KMT2A | |
| SCHEMBL8762892 | 0.88 | OPRM1 (0.76) | OPRM1OPRK1SIGMAR1 | |
| SCHEMBL8761957 | 0.88 | OPRM1 (0.76) | OPRM1OPRK1SIGMAR1 | |
| SCHEMBL8761953 | 0.88 | OPRM1 (0.76) | OPRM1OPRK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10368227 | 0.87 | OPRM1 (0.74) | OPRM1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147085-B1 | SUBSTITUTED TRANS-1.2-DIAMINOCYCLOHEXYL AMIDE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1990-03-14 | — | — | EP | claimed |
| EP-0147085-B1 | SUBSTITUTED TRANS-1.2-DIAMINOCYCLOHEXYL AMIDE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4738981-A | ANALGESICS | WARNER-LAMBERT (US) | 1988-04-19 | — | — | US | disclosed |
| US-4656182-A | ANALGESICS, DIURETICS, PSYCHOTHERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0147085-A2 | Substituted trans-1.2-diaminocyclohexyl amide compounds | WARNER-LAMBERT COMPANY (US) | 1985-07-03 | — | — | EP | disclosed |