SCHEMBL10366369

SCHEMBL10366369

COc1cc(OC)nc(Oc2ccccc2C(O)=S)n1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.59
ALDH1A1 P00352 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
CYP1A2 P05177 3/20 0.57
CYP2C9 P11712 3/20 0.57
CYP2C19 P33261 3/20 0.57
CYP3A4 P08684 2/20 0.57
ATM Q13315 1/20 0.56
GAA P10253 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3886220 0.86 NPSR1 (0.67) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL9380381 0.86 ALDH1A1 (0.45) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL9221677 0.84 HTT (0.67) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL9266255 0.82 NPSR1 (0.63) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL2976362 0.81 ALDH1A1 (0.85) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL9545929 0.81 NPSR1 (0.72) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL10366841 0.79 NPSR1 (0.63) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL10366685 0.78 ALDH1A1 (0.81) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL7851367 0.78 NPSR1 (0.69) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9
SCHEMBL9693631 0.78 NPSR1 (0.62) NPSR1ALDH1A1SMN1; SMN2CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0223406-B1 PYRIMIDINE DERIVATIVES AND HERBICIDAL USES THEREOF KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1990-08-29 EP disclosed
US-4770691-A HERBICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1988-09-13 US disclosed
EP-0223406-A1 Pyrimidine derivatives and herbicidal uses thereof KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1987-05-27 EP disclosed