Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.61 |
| ▸ | PPARG | P37231 | 9/20 | 0.60 |
| ▸ | PPARA | Q07869 | 7/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364994 | 1.00 | HPGD (0.61) | HPGDPPARGPPARAPIM1PIM2 | |
| SCHEMBL10364971 | 1.00 | HPGD (0.61) | HPGDPPARGPPARAPIM1PIM2 | |
| SCHEMBL10365493 | 0.90 | HPGD (0.61) | HPGDPPARGPPARAPIM1PIM2 | |
| SCHEMBL10365494 | 0.90 | HPGD (0.61) | HPGDPPARGPPARAPIM1PIM2 | |
| SCHEMBL8133136 | 0.90 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL8133138 | 0.90 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL10364996 | 0.90 | PPARG (0.59) | PPARGPPARA | |
| SCHEMBL6978745 | 0.87 | PPARG (0.54) | HPGDPPARGPIM1PIM2 | |
| SCHEMBL9316520 | 0.85 | PIM1 (0.45) | HPGDPPARGPPARAPIM1PIM2 | |
| SCHEMBL9370030 | 0.85 | PIM1 (0.45) | HPGDPPARGPPARAPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |