Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 8/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366704 | 0.87 | HPGD (0.61) | PPARGHPGDPIM1PIM2 | |
| SCHEMBL10364971 | 0.87 | HPGD (0.61) | PPARGHPGDPIM1PIM2 | |
| SCHEMBL10364994 | 0.87 | HPGD (0.61) | PPARGHPGDPIM1PIM2 | |
| SCHEMBL10365494 | 0.85 | HPGD (0.61) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL10365493 | 0.85 | HPGD (0.61) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL6967467 | 0.83 | PPARG (0.53) | PPARG | |
| SCHEMBL6966749 | 0.80 | HPGD (0.69) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL6966747 | 0.80 | HPGD (0.69) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL9316506 | 0.80 | LMNA (0.47) | PPARGHPGDPIM1PIM2PTPN1 | |
| SCHEMBL12521887 | 0.79 | PPARG (0.62) | PPARGHPGDPIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |