Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | FPR1 | P21462 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KHK | P50053 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368254 | 0.88 | CNR1 (0.52) | POLBMAPK11MAPK14FPR1NPC1 | |
| SCHEMBL10366777 | 0.88 | CNR1 (0.55) | POLBNPC1RAB9ACNR1CNR2 | |
| SCHEMBL10368043 | 0.88 | MAPK14 (0.48) | MAPK14NPC1RAB9ACNR1CNR2 | |
| SCHEMBL10366036 | 0.87 | CNR1 (0.53) | POLBNPC1RAB9ACNR1CNR2 | |
| SCHEMBL10369901 | 0.84 | PDE4B (0.48) | NTRK1 | |
| SCHEMBL10366047 | 0.83 | CNR1 (0.41) | POLBNPC1RAB9ACNR1CNR2 | |
| SCHEMBL10365918 | 0.82 | CNR1 (0.50) | NPC1RAB9ACNR1CNR2 | |
| SCHEMBL10365971 | 0.82 | MAPK14 (0.50) | POLBMAPK11MAPK14NPC1RAB9A | |
| SCHEMBL10366981 | 0.81 | POLB (0.54) | POLBMAPK11MAPK14FPR1KEAP1 | |
| SCHEMBL6963674 | 0.80 | POLB (0.55) | POLBMAPK14KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4589905-A | TERRESTRIAL AND AQUATIC APPLICATIONS | ELI LILLY AND COMPANY (US) | 1986-05-20 | — | — | US | claimed |
| EP-0151867-B1 | CYANOPYRAZOLE HERBICIDES | ELI LILLY AND COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4589905-A | TERRESTRIAL AND AQUATIC APPLICATIONS | ELI LILLY AND COMPANY (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0151867-A2 | Cyanopyrazole herbicides | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |