Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10892897 | 0.88 | XDH (0.43) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10365977 | 0.88 | RIPK2 (0.63) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10366100 | 0.86 | XDH (0.45) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL2870416 | 0.86 | PTPN1 (0.46) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10893230 | 0.86 | MAPK14 (0.53) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10890676 | 0.86 | RAB9A (0.49) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10366200 | 0.86 | NOTUM (0.52) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10897041 | 0.86 | RXRA (0.50) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10891390 | 0.84 | MAPK14 (0.54) | POLBSMN1; SMN2L3MBTL1NR4A3MAPT | |
| SCHEMBL10897037 | 0.84 | KMT2A (0.53) | L3MBTL1NR4A3KEAP1NFE2L2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631343-A | Cyanopyrazole intermediates | ELI LILLY AND COMPANY (US) | 1986-12-23 | — | — | US | claimed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-4631343-A | Cyanopyrazole intermediates | ELI LILLY AND COMPANY (US) | 1986-12-23 | — | — | US | disclosed |