Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364983 | 0.89 | HPGD (0.55) | NPC1RAB9AHPGDNR4A3MAPT | |
| SCHEMBL10364979 | 0.84 | HPGD (0.53) | NPC1RAB9AHPGDNR4A3MAPT | |
| SCHEMBL10365369 | 0.82 | MAPK14 (0.53) | NPC1RAB9AHPGDNR4A3ALDH1A1 | |
| SCHEMBL10366102 | 0.81 | HPGD (0.50) | NPC1RAB9AHPGDNR4A3MAPT | |
| SCHEMBL10365217 | 0.81 | ALDH1A1 (0.71) | HPGDNR4A3MAPTALDH1A1KMT2A | |
| SCHEMBL20250838 | 0.79 | NR4A3 (0.56) | NPC1RAB9AHPGDNR4A3MAPT | |
| SCHEMBL10366981 | 0.77 | POLB (0.54) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL17324822 | 0.77 | MAPK1 (0.69) | NPC1RAB9AHPGDNR4A3MAPT | |
| SCHEMBL3076270 | 0.77 | MAPT (0.59) | NPC1RAB9ANR4A3MAPTALDH1A1 | |
| SCHEMBL10366472 | 0.76 | TRPC3 (0.48) | NPC1RAB9AHPGDMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151866-B1 | HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
| US-4620865-A | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides | ELI LILLY AND COMPANY (US) | 1986-11-04 | — | — | US | disclosed |
| EP-0151866-A2 | Herbicidal pyrazole-(thio)-carboxamides | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |