Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 14/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365100 | 0.95 | STK17A (0.51) | STK17ASYKSTK17BNPC1ALDH1A1 | |
| SCHEMBL10732356 | 0.81 | STK17A (0.48) | STK17ASYKAURKAJAK1KDR | |
| SCHEMBL10365097 | 0.79 | MAPT (0.47) | STK17ASYKSTK17BNPC1ALDH1A1 | |
| SCHEMBL10732016 | 0.79 | STK17A (0.47) | STK17ASYKAURKAJAK1KDR | |
| SCHEMBL10366902 | 0.78 | STK17A (0.33) | STK17ASYKNPC1ALDH1A1 | |
| SCHEMBL19260116 | 0.76 | ALDH1A1 (0.40) | NPC1ALDH1A1 | |
| SCHEMBL10367439 | 0.76 | STK17A (0.51) | STK17ASTK17B | |
| SCHEMBL10731426 | 0.76 | STK17A (0.51) | STK17ASYKSTK17B | |
| SCHEMBL10365885 | 0.76 | STK17A (0.33) | STK17ASYKNPC1ALDH1A1 | |
| SCHEMBL7751879 | 0.75 | ALDH1A1 (0.40) | STK17AAURKAKDRLRRK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206623-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-10-24 | — | — | EP | disclosed |
| US-4771058-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-09-13 | — | — | US | disclosed |
| EP-0206623-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-12-30 | — | — | EP | disclosed |