Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 15/20 | 0.47 |
| ▸ | STK17B | O94768 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365100 | 0.83 | STK17A (0.51) | STK17ASTK17BSYK | |
| SCHEMBL10731426 | 0.83 | STK17A (0.51) | STK17ASTK17BSYK | |
| SCHEMBL10367439 | 0.83 | STK17A (0.51) | STK17ASTK17B | |
| SCHEMBL18257289 | 0.80 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL10367108 | 0.79 | STK17A (0.47) | STK17ASTK17BSYKAURKAJAK1 | |
| SCHEMBL10732356 | 0.79 | STK17A (0.48) | STK17ASTK17BSYKAURKAJAK1 | |
| SCHEMBL10733600 | 0.77 | KAT2B (0.58) | STK17ASTK17B | |
| SCHEMBL15945540 | 0.76 | NOS3 (0.37) | NOS3NOS1NOS2JAK1 | |
| SCHEMBL21365185 | 0.76 | STK17A (0.47) | STK17ASTK17B | |
| SCHEMBL10738299 | 0.72 | STK17A (0.49) | STK17ASTK17BAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112707-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H1-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-11-04 | — | — | EP | disclosed |
| US-4652650-A | Pyridylaminoalkylamine intermediates | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-24 | — | — | US | disclosed |
| US-4548940-A | Pyridylaminoalkylaminopyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-22 | — | — | US | disclosed |
| EP-0112707-A2 | Aminopyrimidinone derivatives as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-04 | — | — | EP | disclosed |