Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | KIF11 | P52732 | 6/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660566 | 0.88 | SMYD3 (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20291379 | 0.81 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL25124380 | 0.80 | KIF11 (0.61) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20291376 | 0.80 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20291405 | 0.80 | PKM (0.58) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL10365651 | 0.80 | CRBN (0.64) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20291249 | 0.80 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL10366740 | 0.79 | HDAC3 (0.61) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL10366850 | 0.78 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20291247 | 0.78 | HDAC1 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145010-B1 | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4593035-A | FOR TREATING HEART DISEASE | OTSUKA PHARMACEUTICAL COMPANY LIMITED (JP) | 1986-06-03 | — | — | US | disclosed |
| EP-0145010-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |