SCHEMBL1036718

SCHEMBL1036718

CC1CCN(Cc2ccccc2)C[C@H]1O

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.62
ACHE P22303 3/20 0.60
FUCA1 P04066 2/20 0.60
SLC18A3 Q16572 1/20 0.57
MAPT P10636 1/20 0.53
BCHE P06276 2/20 0.51
BACE1 P56817 2/20 0.51
GBA1 P04062 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
CCR3 P51677 1/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
SIGMAR1 Q99720 2/20 0.49
GRIN1 Q05586 1/20 0.49
GRIN2B Q13224 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL736285 1.00 ALDH1A1 (0.62) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL736287 1.00 ALDH1A1 (0.62) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL736286 1.00 ALDH1A1 (0.62) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL28461967 1.00 ALDH1A1 (0.62) ALDH1A1ACHEFUCA1SLC18A3MAPT
Hydrochloric Acid SCHEMBL28093868 0.98 ALDH1A1 (0.60) ALDH1A1ACHEFUCA1SLC18A3MAPT
Alcohol SCHEMBL7113880 0.95 ALDH1A1 (0.57) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL5745121 0.92 ALDH1A1 (0.54) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL765298 0.87 ACHE (0.60) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL914717 0.87 ACHE (0.60) ALDH1A1ACHEFUCA1SLC18A3MAPT
SCHEMBL10267804 0.87 ACHE (0.60) ALDH1A1ACHEFUCA1SLC18A3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2276731-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 Boehringer Ingelheim International GmbH (DE) 2011-01-26 EP disclosed
WO-2009126675-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-10-15 WO disclosed
EP-1286967-A1 CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME LTD. (GB) 2003-03-05 EP disclosed
WO-2001087838-A1 CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME LIMITED (GB) 2001-11-22 WO disclosed