Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 9/20 | 0.43 |
| ▸ | DRD4 | P21917 | 9/20 | 0.43 |
| ▸ | DRD3 | P35462 | 9/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368729 | 0.87 | HRH3 (0.41) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL14220549 | 0.84 | HTR1A (0.48) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL9739692 | 0.83 | CYP4F2 (0.49) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL27280905 | 0.83 | CYP4F2 (0.49) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL9151737 | 0.83 | CYP4F2 (0.49) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL9153673 | 0.83 | HTR1A (0.66) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL9153669 | 0.83 | HTR1A (0.66) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL6282395 | 0.82 | DRD2 (0.65) | DRD2DRD4DRD3DRD1DRD5 | |
| SCHEMBL10366696 | 0.81 | TDP1 (0.48) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL9151283 | 0.81 | HTR1A (0.45) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0207605-A1 | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |