Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 | P05023 | 2/20 | 0.54 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.54 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.54 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.54 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.54 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.54 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.54 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.54 |
| ▸ | TACR3 | P29371 | 11/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | TACR2 | P21452 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368710 | 0.79 | TACR3 (0.43) | TACR3HDAC4HDAC1HDAC6TACR2 | |
| SCHEMBL10367535 | 0.71 | ADORA1 (0.52) | HDAC1HDAC6ADORA1 | |
| SCHEMBL7215986 | 0.70 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL10367693 | 0.70 | ATP1A1 (0.42) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL10367538 | 0.68 | ADORA1 (0.50) | HDAC1ADORA1GAAMAPT | |
| SCHEMBL10371119 | 0.68 | ADORA1 (0.50) | HDAC1ADORA1GAAMAPT | |
| SCHEMBL10368712 | 0.68 | ADORA1 (0.36) | TACR3ADORA1CYP1A2CYP2C9GAA | |
| SCHEMBL8523815 | 0.67 | AKT1 (0.43) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL10367658 | 0.65 | ATP1A1 (0.41) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL22116993 | 0.64 | HDAC6 (0.82) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0210044-A2 | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-01-28 | — | — | EP | disclosed |