Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363737 | 0.81 | CES1 (0.59) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL10367966 | 0.81 | CES1 (0.62) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL9178459 | 0.81 | CES1 (0.62) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL9170783 | 0.81 | CES1 (0.62) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL8768338 | 0.77 | CES1 (1.00) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL9470716 | 0.76 | CES1 (0.56) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL9172070 | 0.76 | CES1 (0.56) | CES1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL11717588 | 0.75 | NPC1 (0.57) | MAPTKMT2AGAA | |
| SCHEMBL14305454 | 0.75 | CYP11B1 (0.54) | KMT2A | |
| SCHEMBL749609 | 0.72 | CES1 (0.90) | CES1ALDH1A1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147805-B1 | SPIRO-LINKED PYRROLIDINE-2,5-DIONES AND PROCESS FOR THEIR PREPARATION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-10-10 | — | — | EP | disclosed |
| US-4593092-A | Spiro-linked pyrrolidin-2,5-dione | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| EP-0147805-A2 | Spiro-linked pyrrolidine-2,5-diones and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-10 | — | — | EP | disclosed |