Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749609 | 0.95 | CES1 (0.90) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL2429208 | 0.93 | CES1 (0.88) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL9391540 | 0.89 | CES1 (0.81) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL10367966 | 0.77 | CES1 (0.62) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL9170783 | 0.77 | CES1 (0.62) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL10367642 | 0.77 | CES1 (0.62) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL9178459 | 0.77 | CES1 (0.62) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL6306471 | 0.76 | CES1 (0.60) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL5363737 | 0.74 | CES1 (0.59) | CES1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL1762224 | 0.73 | CES1 (0.57) | CES1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151282-A | USING 5,6-DIHYDRO-4H-PYRROLO(3,2,1-IJ)QUINOLINE-1,2-DIONE | A. H. ROBINS COMPANY, INC. (US) | 1979-04-24 | — | — | US | claimed |
| JP-60243088-A | — | — | None | — | — | JP | disclosed |
| EP-0402862-B1 | 8-Carboxy-1,2,3,4-tetrahydroquinolin-6-yl-acetic acid and process for its preparation | KYORIN SEIYAKU KK (JP) | 1997-09-10 | — | — | EP | disclosed |
| EP-0310096-B1 | Novel cyclic anthranilic acid derivatives and process for their preparation | KYORIN SEIYAKU KK (JP) | 1995-04-19 | — | — | EP | disclosed |
| US-5281600-A | Antiinflammatory agents, rheumatic diseases and immunomodulators | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5242912-A | Treatment of autoimmune and rheumatic diseases and osteoporosis | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| EP-0402859-B1 | THERAPEUTIC AGENTS OF METABOLIC BONE DISEASE | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5147874-A | Antiarthritic agents | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| US-5124325-A | Administering to inhibit bone resorption | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-06-23 | — | — | US | disclosed |
| US-5120743-A | Aids, metabolic bone diseases | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0310096-A2 | Novel cyclic anthranilic acid derivatives and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |
| US-4593092-A | Spiro-linked pyrrolidin-2,5-dione | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| JP-S60243088-A | ISATIN DERIVATIVE HAVING 1,7-BOND AND ITS PREPARATION | KYORIN PHARMACEUT CO LTD | 1985-12-03 | — | — | JP | disclosed |
| EP-0147805-A2 | Spiro-linked pyrrolidine-2,5-diones and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-10 | — | — | EP | disclosed |
| US-4438126-A | Lower alkanoic acid derivatives of 2-oxo-benzoxazolines and aldose reductase inhibiting compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0022317-B1 | 2-OXO-BENZOTHIAZOLINE, BENZOXAZOLINE OR INDOLINE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-09-21 | — | — | EP | disclosed |
| US-4370340-A | ANTIDIABETIC AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| EP-0022317-A1 | 2-Oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-01-14 | — | — | EP | disclosed |
| US-4151282-A | USING 5,6-DIHYDRO-4H-PYRROLO(3,2,1-IJ)QUINOLINE-1,2-DIONE | A. H. ROBINS COMPANY, INC. (US) | 1979-04-24 | — | — | US | disclosed |
| US-4151282-A | USING 5,6-DIHYDRO-4H-PYRROLO(3,2,1-IJ)QUINOLINE-1,2-DIONE | A. H. ROBINS COMPANY, INC. (US) | 1979-04-24 | — | — | US | disclosed |