Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369583 | 0.83 | SCN9A (0.43) | ESR1ESR2SCN9A | |
| SCHEMBL10367691 | 0.83 | ESR1 (0.50) | ESR1ESR2SCN9ATAAR1 | |
| SCHEMBL14215349 | 0.81 | HPGD (0.48) | ESR1ESR2 | |
| SCHEMBL10503330 | 0.76 | SCN9A (0.45) | ESR1ESR2SCN9A | |
| SCHEMBL6337120 | 0.73 | CA12 (0.52) | ESR1ESR2SCN9A | |
| SCHEMBL10369766 | 0.72 | ALDH1A1 (0.38) | — | |
| SCHEMBL10502715 | 0.71 | SCN9A (0.44) | ESR1ESR2SCN9A | |
| SCHEMBL10503381 | 0.71 | SCN9A (0.44) | ESR1ESR2SCN9A | |
| SCHEMBL10367889 | 0.71 | IGF1R (0.42) | ESR1ESR2 | |
| SCHEMBL4441801 | 0.71 | MAPT (0.60) | ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | disclosed |