Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.34 |
| ▸ | PRKCA | P17252 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369297 | 0.89 | DAGLA (0.33) | DAGLACNR1 | |
| SCHEMBL10368014 | 0.84 | DAGLA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10368015 | 0.84 | DAGLA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10370163 | 0.80 | DAGLA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10367942 | 0.80 | DAGLA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL10371091 | 0.74 | DAGLA (0.34) | DAGLACNR1 | |
| SCHEMBL10371088 | 0.74 | DAGLA (0.34) | DAGLACNR1 | |
| SCHEMBL10367940 | 0.73 | PRKCA (0.41) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL9824730 | 0.73 | PRKCA (0.34) | DAGLAPRKCAPRKD3PRKCGPRKCB | |
| SCHEMBL9825431 | 0.69 | DAGLA (0.38) | DAGLAPRKCAPRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293132-B1 | ANTIHYPERCHOLESTEROLEMIC BETA-LACTONES | MERCK & CO. INC. (US) | 1990-11-14 | — | — | EP | claimed |
| US-4873260-A | B-LACTONE ALKYLENE CARBOXYLIC ACIDS AND DERIVATIVES | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4806564-A | Antihypercholesterolemic beta-lactones | MERCK & CO., INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0293132-A1 | Antihypercholesterolemic beta-lactones | MERCK & CO. INC. (US) | 1988-11-30 | — | — | EP | disclosed |