SCHEMBL10368142

SCHEMBL10368142

Nc1nn(CCCN2CCCCC2)c2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BCHE P06276 3/20 0.46
CNR1 P21554 3/20 0.46
CNR2 P34972 3/20 0.46
HTR7 P34969 8/20 0.46
HRH3 Q9Y5N1 1/20 0.43
TMEM97 Q5BJF2 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10832093 1.00 BCHE (0.46) BCHECNR1CNR2HTR7HRH3
SCHEMBL10369845 0.99 BCHE (0.45) BCHECNR1CNR2HTR7HRH3
SCHEMBL10832212 0.96 HTR7 (0.50) BCHECNR1CNR2HTR7HRH3
SCHEMBL10831065 0.91 BCHE (0.54) BCHECNR1CNR2HTR7HRH3
SCHEMBL11204616 0.91 BCHE (0.54) BCHECNR1CNR2HTR7HRH3
Hydrochloric Acid SCHEMBL10831337 0.90 BCHE (0.53) BCHECNR1CNR2HTR7SIGMAR1
SCHEMBL10831536 0.87 HTR7 (0.46) HTR7SIGMAR1
SCHEMBL10369201 0.86 HTR7 (0.47) CNR1CNR2HTR7SIGMAR1LMNA
SCHEMBL10831393 0.84 KCNA3 (0.42) HTR7TMEM97SIGMAR1
SCHEMBL10831480 0.84 HTR7 (0.39) HTR7TMEM97SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0090972-B1 INDAZOLE DERIVATIVES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1990-05-30 EP disclosed
US-4751302-A ANTIINFLAMMATORY, ANTIULCER AGENTS, ANALGESICS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-06-14 US disclosed
US-4585869-A ANTIINFLAMMATORY, ANALGESIC, ANTIULCER ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1986-04-29 US disclosed
US-4549023-A ANTINFLAMMATORY AGENTS, ANALGESICS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1985-10-22 US disclosed
US-4533731-A ANTIINFLAMMATORY AGENTS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1985-08-06 US disclosed
EP-0049779-B1 3-AMINOINDAZOLE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1984-10-31 EP disclosed
US-4474964-A 3-Aminoindazole derivatives ASAHI, KASEI, KOGYO, KABUSHIKI, KAISHA (JP) 1984-10-02 US disclosed
EP-0090972-A2 Indazole derivatives Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1983-10-12 EP disclosed
EP-0049779-A1 3-Aminoindazole derivatives and process for preparation thereof Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1982-04-21 EP disclosed