SCHEMBL10369201

SCHEMBL10369201

Nc1nn(CCCN2CCOCC2)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 2/20 0.47
KDM4E B2RXH2 3/20 0.46
GAA P10253 2/20 0.46
HSD17B10 Q99714 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
POLB P06746 3/20 0.46
SIGMAR1 Q99720 1/20 0.46
PARP1 P09874 2/20 0.45
TSHR P16473 2/20 0.45
KMT2A Q03164 2/20 0.45
NPC1 O15118 1/20 0.45
LMNA P02545 1/20 0.45
GLA P06280 1/20 0.45
RAD52 P43351 1/20 0.45
RAB9A P51151 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
CNR2 P34972 2/20 0.45
CNR1 P21554 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10369871 0.93 CNR1 (0.50) HTR7KDM4EGAAHSD17B10ALDH1A1
SCHEMBL30860188 0.93 CNR1 (0.50) HTR7KDM4EGAAHSD17B10ALDH1A1
SCHEMBL10369845 0.87 BCHE (0.45) HTR7CNR2CNR1GSK3BPRKCG
SCHEMBL10368142 0.86 BCHE (0.46) HTR7SIGMAR1LMNACNR2CNR1
SCHEMBL10832093 0.86 BCHE (0.46) HTR7SIGMAR1LMNACNR2CNR1
SCHEMBL10831536 0.85 HTR7 (0.46) HTR7KDM4EHSD17B10POLBSIGMAR1
SCHEMBL10832212 0.82 HTR7 (0.50) HTR7SIGMAR1CNR2CNR1
SCHEMBL10369107 0.82 CNR2 (0.43) KDM4EGAAALDH1A1POLBKMT2A
SCHEMBL10370645 0.82 MAPT (0.50) KDM4EALDH1A1HPGDPOLBTSHR
SCHEMBL10831480 0.82 HTR7 (0.39) HTR7KDM4EHSD17B10SIGMAR1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0090972-B1 INDAZOLE DERIVATIVES Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1990-05-30 EP disclosed
US-4751302-A ANTIINFLAMMATORY, ANTIULCER AGENTS, ANALGESICS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-06-14 US disclosed
US-4533731-A ANTIINFLAMMATORY AGENTS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1985-08-06 US disclosed
EP-0090972-A2 Indazole derivatives Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1983-10-12 EP disclosed