Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10391021 | 0.78 | CA2 (0.60) | CA2 | |
| SCHEMBL10370361 | 0.76 | CA2 (1.00) | CA2 | |
| SCHEMBL10391075 | 0.72 | CA2 (0.50) | CA2 | |
| SCHEMBL10390690 | 0.71 | CA2 (0.63) | CA2 | |
| SCHEMBL9828407 | 0.71 | CA2 (0.60) | CA2SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL21963164 | 0.70 | CA2 (0.50) | CA2 | |
| SCHEMBL29405336 | 0.70 | ALDH1A1 (0.64) | CA2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1698928 | 0.70 | ALDH1A1 (0.64) | CA2KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL9827904 | 0.68 | CA2 (1.00) | CA2SLC6A2SLC6A4SLC6A3KDM4E | |
| Hydrochloric Acid SCHEMBL29426319 | 0.68 | CA2 (0.97) | CA2SLC6A2SLC6A4SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268396-B1 | 4-(BENZOYL)THIOPHENE(OR FURAN)-SULFONAMIDE AND DERIVATIVES THEREOF FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURES | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | claimed |
| EP-0268396-A1 | 4-(benzoyl)thiophene(or furan)-sulfonamide and derivatives thereof for the topical treatment of elevated intraocular pressures | MERCK & CO. INC. (US) | 1988-05-25 | — | — | EP | claimed |