Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | SI | P14410 | 1/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369219 | 0.89 | GAA (0.48) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL10743514 | 0.89 | GAA (0.48) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL11626548 | 0.81 | GAA (0.52) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL23360566 | 0.77 | THRB (0.46) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL11179101 | 0.77 | GAA (0.64) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL10366624 | 0.77 | MGAM (0.47) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL20125904 | 0.77 | ZDHHC20 (0.40) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL7104102 | 0.75 | CA12 (0.53) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL23765759 | 0.75 | CA12 (0.39) | GAAMGAMSIMGAM2CA12 | |
| SCHEMBL19317379 | 0.74 | CA12 (0.52) | GAAMGAMSIMGAM2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178759-B1 | ALKYNYL DERIVATIVESOF PYRAZOLO-(3,4-B)-PYRIDINE LACTAMS | ICI AMERICAS INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4705793-A | Pyrazolo[3,4-b]pyrrolo[3,4-e]pyridine-5(1H)-one and 1-H-pyrazolo[3,4-b][1,6]naphthyridine-5(6H)-one derivations, useful as anti-anxiety agents | ICI AMERICAS INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4645838-A | Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents | ICI AMERICAS INC. (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0094175-B1 | PYRAZOLOPYRIDINE COMPOUNDS | ICI AMERICAS INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| EP-0178759-A1 | Alkynyl derivativesof pyrazolo-(3,4-b)-pyridine lactams | ICI AMERICAS INC. (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4563525-A | Process for preparing pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4511568-A | CNS-Depressant pyrazolopyridines | ICI AMERICAS INC. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0094175-A1 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-11-16 | — | — | EP | disclosed |