Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372093 | 0.92 | DRD3 (0.60) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL10370891 | 0.92 | DRD3 (0.59) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL10397519 | 0.81 | DRD3 (0.58) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL4501475 | 0.80 | DRD3 (0.71) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| Nonaperone SCHEMBL2109345 | 0.80 | DRD3 (0.67) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL8989763 | 0.79 | DRD3 (0.53) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL8989690 | 0.79 | DRD2 (0.67) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL7781094 | 0.76 | DRD2 (0.60) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL4496558 | 0.75 | TSHR (0.76) | DRD3HTR1AMEN1CHRM2ADRA2A | |
| SCHEMBL8989694 | 0.75 | DRD2 (0.53) | DRD3DRD2DRD4KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4937347-A | Polycyclicamine with psychotropic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-06-26 | — | — | US | disclosed |
| US-4927934-A | Polycyclicamine with psychotropic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0348460-A1 | POLYCYCLICAMINES WITH PSYCHOTROPIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4855430-A | Polycyclicamine with psychotropic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-08 | — | — | US | disclosed |