Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063384 | 0.79 | FABP6 (0.44) | TDP2NSD2ABL1PLCG1CES1 | |
| SCHEMBL479824 | 0.74 | GRM5 (0.46) | GRM5MAPTHSD17B10ACHE | |
| SCHEMBL304791 | 0.74 | GRM5 (0.46) | GRM5MAPTHSD17B10ACHE | |
| SCHEMBL1404621 | 0.68 | GRM5 (0.48) | GRM5TDP2NSD2ABL1PLCG1 | |
| SCHEMBL29960907 | 0.68 | ACHE (0.35) | GRM5TDP2NSD2ABL1PLCG1 | |
| SCHEMBL21802122 | 0.67 | ALDH1A1 (0.36) | HTTLMNACYP3A4MAPTALOX15 | |
| SCHEMBL10199987 | 0.67 | SSTR4 (0.40) | SMN1; SMN2PDE1APDE1CPDE1B | |
| SCHEMBL31111396 | 0.67 | SSTR4 (0.40) | SMN1; SMN2PDE1APDE1CPDE1B | |
| SCHEMBL24077529 | 0.66 | PRKCI (0.35) | GRM5MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL2110952 | 0.66 | SSTR4 (0.39) | KDM4ESMN1; SMN2PDE1APDE1CPDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107930-B1 | FUSED AROMATIC OXAZEPINONES AND SULPHUR ANALOGUES THEREOF AND THEIR PREPARATION AND USE IN COUNTERACTING HISTAMINE | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1990-11-28 | — | — | EP | claimed |