Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679632 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL1190527 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL16549824 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL103705 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL103704 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL1190919 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971721 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971725 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL4187485 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971723 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510416-A | Preparation method of (2R, 5S) -4-Boc-2, 5-dimethylpiperazine | 浙江普洛康裕制药有限公司 | 2024-02-06 | — | — | CN | disclosed |
| EP-2847191-B1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2016-06-15 | — | — | EP | disclosed |
| EP-2760862-B1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2015-10-21 | — | — | EP | disclosed |
| US-9133181-B2 | Substituted 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors | SANOFI (FR) | 2015-09-15 | — | — | US | disclosed |
| US-20150133432-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2015-05-14 | — | — | US | disclosed |
| EP-2847191-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2015-03-18 | — | — | EP | disclosed |
| EP-2760862-A1 | 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013167403-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2013-11-14 | — | — | WO | disclosed |
| EP-2426113-B1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | KOWA CO (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-8551985-B2 | Carbinol derivatives having heterocyclic linker | KOWA COMPANY, LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20030195355-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2003-10-16 | — | — | US | disclosed |
| EP-1341782-A2 | INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| US-20030162970-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030158417-A1 | Benzofuran derivatives as inhibitors of p38-alpha kinase | SCIOS, INC. | 2003-08-21 | — | — | US | disclosed |
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAVUNKEL BABU J (US) | 2003-07-31 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| US-20030092717-A1 | Inhibitors of p38 kinase | SCIOS, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2002042292-A2 | INDOL DERIVATIVE AND THEIR USE AS INHIBITORS OF P38 KINASE | SCIOS INC. (US) | 2002-05-30 | — | — | WO | disclosed |
| EP-1178983-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071535-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2000-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133432-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | MAP3K1, MAP3K6, MAP3K19 | SIGMAR1 3451/4885MAPT 2710/4885PDK1 91/4885 |
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885MAPT 3875/4885PDK1 1297/4885 |
| US-20030092717-A1 | Inhibitors of p38 kinase | MAPK1, CNKSR1, MOK | SIGMAR1 550/4885MAPT 4013/4885PDK1 955/4885 |
| US-20030158417-A1 | Benzofuran derivatives as inhibitors of p38-alpha kinase | CNKSR1, CSNK2A1, CSNK1A1 | SIGMAR1 527/4885MAPT 4367/4885PDK1 945/4885 |
| US-20030162970-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885MAPT 3875/4885PDK1 1297/4885 |
| US-20030195355-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | SIGMAR1 485/4885MAPT 3875/4885PDK1 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.