Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679632 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL16549824 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL103705 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL103704 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL103706 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| SCHEMBL1190919 | 1.00 | SIGMAR1 (0.68) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971721 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971725 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL4187485 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 | |
| Hydrochloric Acid SCHEMBL7971723 | 0.98 | SIGMAR1 (0.67) | SIGMAR1MAPTPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217226-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| EP-2118112-B1 | 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS | PFIZER (US) | 2015-07-08 | — | — | EP | disclosed |
| US-20130045962-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2013-02-21 | — | — | US | disclosed |
| US-7893056-B2 | Peptide deformylase inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090306066-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2009-12-10 | — | — | US | disclosed |
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130045962-A1 | PEPTIDE DEFORMYLASE INHIBITORS | PDF, DPEP1, DHPS | SIGMAR1 2945/4885MAPT 4508/4885PDK1 546/4885 |
| US-20090306066-A1 | PEPTIDE DEFORMYLASE INHIBITORS | PDF, DHPS, PADI3 | SIGMAR1 1138/4885MAPT 4456/4885PDK1 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.