Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 12/20 | 0.72 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.72 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.72 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370805 | 1.00 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL10370803 | 1.00 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9397786 | 0.85 | ABCC9 (0.65) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9397800 | 0.85 | ABCC9 (0.65) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9397792 | 0.85 | ABCC9 (0.65) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL24658941 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL3771007 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Levcromakalim SCHEMBL30059152 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL25029865 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| (-)-Cromakalim SCHEMBL12833 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172352-B1 | ACTIVE BENZOPYRAN COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-08-29 | — | — | EP | claimed |