Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.54 |
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291472 | 0.88 | HRH3 (0.70) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7300116 | 0.86 | HRH3 (0.68) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7327130 | 0.82 | HRH3 (0.60) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL1376025 | 0.82 | HRH3 (1.00) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10423532 | 0.82 | HRH3 (0.60) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL1376834 | 0.82 | HRH3 (1.00) | HRH3PDE3BPDE3AKCNH2 | |
| SCHEMBL10369572 | 0.81 | HRH3 (0.59) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10423533 | 0.81 | HRH3 (0.59) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL4064155 | 0.81 | HRH3 (0.61) | HRH3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10353457 | 0.81 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258519-A | FOR TREATMENT OF HYPERTENSION AND CARDIAC CONDITIONS | GLAXO INC. (US) | 1993-11-02 | — | — | US | disclosed |
| US-5100892-A | Hypotensive agents, congestive heart failure | GLAXO INC. (US) | 1992-03-31 | — | — | US | disclosed |