Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371207 | 0.86 | ATR (0.44) | ATRCHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL10369755 | 0.80 | CHRM3 (0.55) | CHRM1CHRM3CHRM4CHRM5KDM4E | |
| SCHEMBL15779519 | 0.77 | ATR (0.46) | ATRCHRM1CHRM3CHRM2 | |
| SCHEMBL15779517 | 0.77 | ATR (0.46) | ATRCHRM1CHRM3CHRM2 | |
| SCHEMBL10568167 | 0.75 | IKBKB (0.54) | ATRIKBKBCHUK | |
| SCHEMBL10564465 | 0.75 | RPS6KB1 (0.47) | ATRCHRM1CHRM3CHRM4CHRM5 | |
| Fumaric Acid SCHEMBL10370924 | 0.73 | HRH1 (0.44) | ATRCHRM1CHRM3CHRM4CHRM5 | |
| Fumaric Acid SCHEMBL10372505 | 0.73 | HRH1 (0.44) | ATRCHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL10370980 | 0.73 | KMT2A (0.47) | CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL10370253 | 0.73 | ALDH1A1 (0.52) | CHRM1CHRM3CHRM4CHRM5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107930-B1 | FUSED AROMATIC OXAZEPINONES AND SULPHUR ANALOGUES THEREOF AND THEIR PREPARATION AND USE IN COUNTERACTING HISTAMINE | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1990-11-28 | — | — | EP | disclosed |
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4727152-A | Intermediates useful in the preparation of fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0107930-A2 | Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1984-05-09 | — | — | EP | disclosed |