Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.54 |
| ▸ | CHUK | O15111 | 4/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369009 | 0.86 | IRAK4 (0.55) | IRAK4CHEK2 | |
| SCHEMBL10562808 | 0.80 | ATR (0.44) | IKBKBCHUKCHEK2ATR | |
| SCHEMBL10564465 | 0.80 | RPS6KB1 (0.47) | ATRMKNK1MKNK2 | |
| SCHEMBL10566359 | 0.79 | RPS6KB1 (0.44) | IKBKBIRAK4CHEK2ATRMKNK1 | |
| SCHEMBL10368953 | 0.76 | HTR2C (0.46) | CHEK2 | |
| SCHEMBL29548907 | 0.76 | MKNK1 (0.53) | IKBKBCHUKIRAK4MKNK1MKNK2 | |
| SCHEMBL17913360 | 0.76 | MKNK1 (0.53) | IKBKBCHUKIRAK4MKNK1MKNK2 | |
| SCHEMBL17913502 | 0.76 | MKNK1 (0.53) | IKBKBCHUKIRAK4MKNK1MKNK2 | |
| SCHEMBL10370253 | 0.76 | ALDH1A1 (0.52) | — | |
| SCHEMBL18427749 | 0.75 | IRAK4 (0.69) | IRAK4MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4727152-A | Intermediates useful in the preparation of fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |