Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10371258 | 0.93 | CHRM3 (0.44) | NOS3NOS1NOS2CHRM4CHRM5 | |
| SCHEMBL10370276 | 0.75 | CHRM4 (0.44) | NOS3NOS1NOS2CHRM4CHRM5 | |
| SCHEMBL24476762 | 0.71 | IMPDH2 (0.53) | KDM4E | |
| SCHEMBL2422193 | 0.70 | CA1 (0.48) | ARKDM4E | |
| SCHEMBL18348315 | 0.69 | HTR2C (0.52) | HRH3PDE10APGR | |
| SCHEMBL3291578 | 0.69 | PDE10A (0.49) | HRH3CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3295720 | 0.68 | SSTR4 (0.50) | HRH3PDE10A | |
| SCHEMBL18348306 | 0.68 | NOS3 (0.49) | NOS3NOS1NOS2HRH3PDE10A | |
| SCHEMBL3130466 | 0.68 | HRH3 (0.55) | HRH3CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31610159 | 0.67 | IMPDH2 (0.45) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107930-B1 | FUSED AROMATIC OXAZEPINONES AND SULPHUR ANALOGUES THEREOF AND THEIR PREPARATION AND USE IN COUNTERACTING HISTAMINE | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1990-11-28 | — | — | EP | claimed |