Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370253 | 0.78 | ALDH1A1 (0.52) | DRD2DRD4SCN1ASCN2ASCN3A | |
| Oxalic Acid SCHEMBL10672874 | 0.76 | KDM4E (0.50) | SCN1ASCN2ASCN3ACHRM4CHRM5 | |
| Oxalic Acid SCHEMBL10372028 | 0.76 | KDM4E (0.50) | SCN1ASCN2ASCN3ACHRM4CHRM5 | |
| SCHEMBL10369009 | 0.74 | IRAK4 (0.55) | SCN1ASCN2ASCN3ACHRM4CHRM5 | |
| SCHEMBL10370276 | 0.67 | CHRM4 (0.44) | CHRM4CHRM5CHRM1CHRM3NOS3 | |
| SCHEMBL10369755 | 0.67 | CHRM3 (0.55) | SCN1ASCN2ASCN3ACHRM4CHRM5 | |
| SCHEMBL10370921 | 0.63 | KCNH2 (0.52) | SCN1ASCN2ASCN3ACHRM4CHRM5 | |
| SCHEMBL10568167 | 0.62 | IKBKB (0.54) | CHEK2 | |
| Oxalic Acid SCHEMBL10371258 | 0.62 | CHRM3 (0.44) | CHRM4CHRM5CHRM1CHRM3NOS3 | |
| SCHEMBL31198254 | 0.61 | CHRM3 (0.48) | CHRM4CHRM5CHRM1CHRM3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107930-B1 | FUSED AROMATIC OXAZEPINONES AND SULPHUR ANALOGUES THEREOF AND THEIR PREPARATION AND USE IN COUNTERACTING HISTAMINE | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1990-11-28 | — | — | EP | disclosed |
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0107930-A2 | Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1984-05-09 | — | — | EP | disclosed |