Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266269 | 0.78 | GPR3 (0.46) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL718497 | 0.72 | GPR3 (0.50) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL10375309 | 0.72 | GPR3 (0.40) | GPR3KDM4ENPC1ALDH1A1TDP1 | |
| SCHEMBL29434786 | 0.72 | GPR3 (0.55) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL1518983 | 0.72 | GPR3 (0.55) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL309376 | 0.72 | GPR3 (0.55) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL3123867 | 0.71 | LIMK1 (0.38) | RAB9AMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL19135547 | 0.70 | GPR3 (0.52) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL9272736 | 0.68 | EGFR (0.43) | GPR3MAPTRAB9AMEN1KMT2A | |
| SCHEMBL24442088 | 0.68 | GPR3 (0.50) | GPR3MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217530-B1 | DIHYDROPYRIDINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4659717-A | CAUSING VASODILATION | ELI LILLY AND COMPANY (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0217530-A1 | Dihydropyridines | ELI LILLY AND COMPANY (US) | 1987-04-08 | — | — | EP | disclosed |