SCHEMBL10373232

SCHEMBL10373232

Cc1cc(N)c(Cl)nc1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.46
CYP3A4 P08684 3/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.40
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALDH1A1 P00352 4/20 0.38
TERT O14746 1/20 0.37
POLB P06746 2/20 0.35
CYP1A2 P05177 2/20 0.35
SLC9A1 P19634 1/20 0.35
KDM4E B2RXH2 2/20 0.34
RAD52 P43351 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
UHRF1 Q96T88 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29959988 0.83 TDP1 (0.41) CD44CYP3A4TSHRMAPK1NOS3
SCHEMBL20856165 0.83 TDP1 (0.41) CD44CYP3A4TSHRMAPK1NOS3
SCHEMBL9686927 0.83 CD44 (0.48) CD44CYP3A4TSHRMAPK1TDP1
SCHEMBL20278433 0.81 CD44 (0.46) CD44CYP3A4TSHRMAPK1NOS3
SCHEMBL1558796 0.77 LMNA (0.39) CD44CYP3A4TSHRMAPK1TDP1
SCHEMBL4136127 0.77 TDP1 (0.37) CD44CYP3A4TDP1TERTSLC9A1
SCHEMBL38665080 0.77 CYP3A4 (0.46) CD44CYP3A4TSHRMAPK1NOS3
SCHEMBL31096856 0.77 ALDH1A1 (0.35) CYP3A4MAPK1NOS3NOS1NOS2
SCHEMBL21587311 0.77 CYP3A4 (0.46) CD44CYP3A4TSHRMAPK1NOS3
SCHEMBL4928726 0.77 ALDH1A1 (0.35) CYP3A4MAPK1NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0076017-B1 PHENYL SUBSTITUTED PYRIDO(1,4)BENZODIAZEPINES AND INTERMEDIATES THEREFOR A.H. ROBINS COMPANY, INCORPORATED (US) 1990-08-16 EP disclosed
US-4668675-A ANTIDEPRESSANTS A. H. ROBINS COMPANY, INCORPORATED (US) 1987-05-26 US disclosed
US-4556667-A (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES A. H. ROBINS COMPANY, INCORPORATED (US) 1985-12-03 US disclosed
US-4495183-A ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS A. H. ROBINS COMPANY, INCORPORATED (US) 1985-01-22 US disclosed
US-4447361-A ANTIDEPRESSANT A. H. ROBINS COMPANY, INC. (US) 1984-05-08 US disclosed
EP-0076017-A2 Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor A.H. ROBINS COMPANY, INCORPORATED (US) 1983-04-06 EP disclosed