Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781404 | 0.83 | CYP19A1 (0.31) | CYP19A1NPSR1 | |
| SCHEMBL9781521 | 0.77 | PRKCI (0.36) | — | |
| SCHEMBL9781455 | 0.74 | KDM4E (0.40) | MAPT | |
| SCHEMBL11032839 | 0.72 | PDE3B (0.51) | CRBN | |
| SCHEMBL10764645 | 0.71 | APP (0.33) | CYP19A1MAPT | |
| SCHEMBL10599346 | 0.70 | GRIA1 (0.31) | — | |
| SCHEMBL7296418 | 0.70 | MAPT (0.34) | CYP19A1CRBNDDB1MAPTATM | |
| SCHEMBL10599501 | 0.70 | VHL (0.31) | — | |
| SCHEMBL9781418 | 0.69 | LMNA (0.45) | MAPTSMN1; SMN2 | |
| SCHEMBL7980719 | 0.69 | CYP19A1 (0.46) | CYP19A1CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231744-B1 | SUBSTITUTED PYRROL-1-YLPHENYLDIHYDROPYRIDAZINONES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0167995-B1 | (PYRROL-1-YL)-PHENYL-DIHYDROPYRIDAZINONES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1989-01-04 | — | — | EP | disclosed |
| US-4415571-A | HYPOTENSIVE AGENTS; THROMBOSIS; ANTICOAGULANTS; CARDIOVASCULAR DISORDDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |