Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 6/20 | 0.52 |
| ▸ | GLA | P06280 | 4/20 | 0.52 |
| ▸ | GFER | P55789 | 4/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373374 | 0.88 | PDE3B (0.68) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10375588 | 0.87 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Adibendan SCHEMBL9832050 | 0.86 | PDE3B (0.90) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Adibendan SCHEMBL10470994 | 0.85 | PDE3B (0.88) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10373612 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10374847 | 0.84 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL10478146 | 0.84 | PDE3B (0.64) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10372929 | 0.83 | PDE3B (0.62) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9677178 | 0.82 | PDE3B (0.75) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10585403 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186010-B1 | PYRROLO BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1990-01-31 | — | — | EP | disclosed |
| US-4810801-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-03-07 | — | — | US | disclosed |
| US-4710510-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-12-01 | — | — | US | disclosed |
| EP-0186010-A1 | Pyrrolo benzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |